Väitöskirjat / Doktorsavhandlingar / Dissertations
2023: Helena Hohtari: Biological Characterization of Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
2021: Eleonora Mäkelä: Novel PP2A biomarkers in cancer
2020: Ciara Tierney: Proteomic Characterisation of Patient Samples Diagnosed with Haematological Malignancies
2019: Ashwini Kumar: Transcriptomic data integration for precision medicine in leukemia
2019: Heta Tarkkala: Reorganizing Biomedical Research Biobanks as Conditions of Possibility for Personalized Medicin
2017: Mika Kontro: Individualizing therapy fo acute leukemia
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Tutkimukset / Studier / Studies
2024
Velasco-Hernandez et al 2024: Integrative single‐cell expression and functional studies unravels a sensitization to cytarabine‐based chemotherapy through HIF pathway inhibition in AML leukemia stem cells. HemaSphere, 8(2), e45. https://doi.org/10.1002/hem3.45
Eldfors et al: Monosomy 7/del(7q) Cause Sensitivity to Inhibitors of Nicotinamide Phosphoribosyltransferase in Acute Myeloid Leukemia. Blood Adv 2024; bloodadvances.2023010435. doi: https://doi.org/10.1182/bloodadvances.2023010435
2023
Katsenou et al 2023: Using Proteomics Data to Identify Personalized Treatments in Multiple Myeloma: A Machine Learning Approach. Int. J. Mol. Sci. 2023, 24, 15570. https://doi.org/10.3390/ijms242115570
Dunphy et al 2023: Proteomic and Metabolomic Analysis of Bone Marrow and Plasma from Patients with Extramedullary Multiple Myeloma Identifies Distinct Protein and Metabolite Signatures. Cancers 15, no. 15: 3764. https://doi.org/10.3390/cancers15153764
Luoma et al 2023: Deep Immune Profiling of Multiple Myeloma at Diagnosis and under Lenalidomide Maintenance Therapy. Cancers 15, no. 9: 2604. https://doi.org/10.3390/cancers15092604
Ennis et al 2023: Cell-cell interactome of the hematopoietic niche and its changes in acute myeloid leukemia. iScience, 26(6), 106943. https://doi.org/10.1016/j.isci.2023.106943
Ianevski et al 2023: Single-cell transcriptomes identify patient-tailored therapies for selective co-inhibition of cancer clones. bioRxiv 2023.06.26.546571; doi: https://doi.org/10.1101/2023.06.26.546571
Casado et al 2023: Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes. Sig Transduct Target Ther 8, 80. https://doi.org/10.1038/s41392-022-01288-1
Lahtinen et al 2023: Clinically relevant germline variants in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant 58, 39–45. https://doi.org/10.1038/s41409-022-01828-x
Valkama et al 2023: Optical Genome Mapping as an Alternative to FISH-Based Cytogenetic Assessment in Chronic Lymphocytic Leukemia. Cancers 15(4):1294. https://doi.org/10.3390/cancers15041294
2022
Kelkka et al 2022: Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia. Leukemia 36, 2317–2327. https://doi.org/10.1038/s41375-022-01654-6
Douglas et al 2022: Enrichment of cancer-predisposing germline variants in adult and pediatric patients with acute lymphoblastic leukemia. Scientific Reports 12(1):10670. doi: 10.1038/s41598-022-14364-x
Velasco-Hernandez et al 2022: A comprehensive single-cell expression atlas of human AML leukemia-initiating cells unravels the contribution of HIF pathway and its therapeutic potential. bioRxiv 2022.03.02.482638; doi: https://doi.org/10.1101/2022.03.02.482638
Flanagan et al 2022: The Peptide–Drug Conjugate Melflufen Modulates the Unfolded Protein Response of Multiple Myeloma and Amyloidogenic Plasma Cells and Induces Cell Death. HemaSphere 6 (3). https://doi.org/10.1097/HS9.0000000000000687
Hohtari et al 2022: Copy number alterations define outcome in Philadelphia chromosome-positive acute lymphoblastic leukemia. Haematologica 107(8):1971-1976. https://doi.org/10.3324/haematol.2021.280578
Hohtari et al 2022: Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B-cell Acute Lymphoblastic Leukemia. Hemasphere 6 (3). https://doi:10.1097/HS9.0000000000000701
2021
Dowling et al 2021: Identification of Protein Biomarker Signatures for Acute Myeloid Leukemia (AML) Using Both Nontargeted and Targeted Approaches. Proteomes 9 (4); 42. https://doi.org/10.3390/proteomes9040042
IIanevski et al 2021: Patient-tailored design for selective co-inhibition of leukemic cell subpopulations. Science advances 7 (8). https://doi.org/10.1126/sciadv.abe4038
Liu, Minxia el al 2021: S100 Calcium Binding Protein Family Members Associate With Poor Patient Outcome and Response to Proteasome Inhibition in Multiple Myeloma. Frontiers in Cell and Developmental Biology 9. https://doi.org/10.3389/fcell.2021.723016
Lundgren et al 2021: Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia. Leukemia 35; 1365-1379. https://doi.org/10.1038/s41375-021-01231-3
Miettinen et al 2021: Aminopeptidase Expression in Multiple Myeloma Associates with Disease Progression and Sensitivity to Melflufen. Cancers 13 (7); 1527. https://doi.org/10.3390/cancers13071527
Mäkelä et al 2021: Discovery of a Novel CIP2A Variant (NOCIVA) with Clinical Relevance in Predicting TKI Resistance in Myeloid Leukemias. Clin Cancer Res 27 (10); 2848-2860. https://doi.org/10.1158/1078-0432.CCR-20-3679
2019
Douglas et al 2019: ERCC6L2 defines a novel entity within inherited acute myeloid leukemia. Blood 133 (25); 2724-2728. https://doi.org/10.1182/blood-2019-01-896233
Dufva et al 2019: Integrated drug profiling and CRISPR screening identify essential pathways for CAR T cell cytotoxicity. Blood 135 (9); 597-609. https://doi.org/10.1182/blood.2019002121
Hohtari et al 2019: Immune cell constitution in bone marrow microenvironment predicts outcome in adult ALL. Leukemia 33; 1570-1582. https://doi.org/10.1038/s41375-018-0360-1
Mäkelä et al 2019: Arpp19 Promotes Myc and Cip2a Expression and Associates with Patient Relapse in Acute Myeloid Leukemia. Cancers 11; 1774. https://doi.org/10.3390/cancers11111774
2018
Wartiovaara-Kautto et al 2018: Germline alterations in a consecutive series of acute myeloid leukemia. Leukemia 32;2282-2285. https://doi.org/10.1038/s41375-018-0049-5
